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目的：：探讨了过敏性紫癜肾损伤患儿治疗前后血清CYSC和尿微量蛋白、β2-m水平的变化及临床意义。方法：应用胶乳增强免疫比浊法和放免法对32例过敏性紫癜肾损伤患儿进行了治疗前后血清CYSC和尿微量蛋白、β2-m水平测定，并与35名正常健康儿作比较。结果：在治疗前，患儿血清CYSC 、尿微量蛋白、β2-m水平均非常显著地高于正常人组（p＜0.01），经治疗1个月后则与正常人比较无显著性差异（p＞0.05），且血清CYSC 水平与尿微量蛋白、β2-m水平呈正相关（r=0.5189,0.6144，p＜0.01）。结论：检测血清CYSC 、尿微量蛋白和β2-m水平的变化可作为早期诊断。“,”Objective To explore The clinical Significance of Changes of Serum Hcysc and urine mAlb、β2-m levels after treatment in patients With purpura nephritis.Methods:Serum cysc(With latex-enhanced immunoturbidimetry assay) ,urine mAlb、β2-m levels (With RIA) levels were determined in 32 patients With purpura nephritis and 35 controls.Results Before treatment,Serum cysc、UmAlb、β2-m levels were Significantly higher than those in Controls(p0.05). Serum cysc levels were positively correlated With UmAlb、β2-m levels(r=0.5189、0.6144,p<0.01).Conclusions Detection of cysc、UmAlb、β2-m levels evel might be used as in indicator for early diagnosis.