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Objective:To assess the correlation of signs of myocardial damage to serum cardiac troponin I(cTnI)and creatine kinase MB isoenzyme(CK-MB)concentrations.Methods:Blood samples were collected from 25 term asphyxiated neonates and 25 controls at 12 h of age by immunoassay.The asphyxiated neonates were followed up until discharge or death.Results:Asphyxiated neonates had significantly higher concentrations of cTnI and CK-MB than controls(P<0.001).Serum cTnI concentrations were significantly higher in asphyxiated neonates who developed hypotension,heart failure or those had low ejection fraction(P<0.01).Serum cTnI concentrations were significantly higher in asphyxiated who died than those who survived(P<0.01).There was no significant difference in serum CK-MB mass concentrations between asphyxiated neonates with and without these complications.Conclusion:Unlike CK-MB,serum cTnI concentrations are significantly higher in asphyxiated neonates who died or developed cardiac dysfunction.
Objective: To assess the correlation of signs of myocardial damage to serum cardiac troponin I (cTnI) and creatine kinase MB isoenzyme (CK-MB) concentrations. Methods: Blood samples were collected from 25 term asphyxiated neonates and 25 controls at 12 h of age by immunoassay.The asphyxiated neonates were followed up until discharge or death. Results: Asphyxiated neonates had significantly higher concentrations of cTnI and CK-MB than controls (P <0.001) .Serum cTnI concentrations were significantly higher in asphyxiated neonates who developed hypotension, heart failure or those had low ejection fractions (P <0.01) .Serum cTnI concentrations were significantly higher in asphyxiated who died than those who survived (P <0.01). There was no significant difference in serum CK-MB mass concentrations between asphyxiated neonates with and without these complications. Conclusions: Unlike CK-MB, serum cTnI concentrations are significantly higher in asphyxiated neonates who died or developed cardiac dysfunction.