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Wenske 等曾报道静注大剂量免疫球蛋白治疗严重的自身免疫性疾患包括妊娠的母亲和新生儿的特发性血小板减少性紫癜。获得良好效果。其作用方式未明,可能包括3个方面:对抗体合成的反馈抑制作用;封闭网状内皮系统 FC 受体;阻断妊娠时 FC介导的抗体通过胎盘。本文作者用大剂量免疫球蛋白静注治疗1例严重的 Rh 免疫的妇女,以改善其胎儿的预后。
Wenske et al have reported intravenous bolus immunoglobulin in the treatment of severe autoimmune disorders including pregnant mothers and neonatal idiopathic thrombocytopenic purpura. Get good results. Its mode of action is unclear and may include three aspects: feedback inhibition of antibody synthesis; closure of the reticuloendothelial system FC receptor; blockage of FC-mediated antibodies across the placenta during pregnancy. The authors of this study used high-dose immunoglobulin intravenous treatment of 1 case of severe Rh-immune women to improve their fetal prognosis.