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目的:对全国51家医院2000年凝固酶阴性葡萄球菌（CNS）耐药性的结果进行统计分析,以探讨CNS的耐药性现状。方法:药敏试验采用纸片扩散法（K-B法）。结果:（1）在3619株CNS中,2330株为凝固酶阴性新生霉素敏感的葡萄球菌（CNS-NovS）、338株为凝固酶阴性新生霉素耐药的葡萄球菌（CNS-NovR）、其它 CNS 951株;（2）甲氧西林耐药的凝固酶阴性新生霉素敏感的葡萄球菌（MRC-NS-NovS）对环丙沙星、红霉素、庆大霉素、氯霉素、克林霉素、复方新诺明和四环素的耐药率分别为57.6％、82.4％、31.9％、44.5％、51.9％、78.2％、58.1％;（3）甲氧西林敏感的凝固酶阴性新生霉素敏感的葡萄球菌（MSCNS-NovS）对环丙沙垦、氯霉素、复方磺胺甲(?)唑和四环素的耐药率较甲氧西林敏感的金黄色葡萄球菌为高,但仍对临床常用抗生素环丙沙星、庆大霉素、氯霉素、克林霉素有较好的敏感性,耐药率分别为25.3％、7.9％、30.9％、23.9％。结论:加强对CNS耐药性的监测是非常必要的。
Objective: To analyze the results of drug resistance of coagulase-negative staphylococci (CNS) in 51 hospitals in China in 2000 in order to investigate the status of CNS drug resistance. Methods: Drug sensitivity test using disk diffusion method (K-B method). Results: (1) Among 3619 CNS strains, 2330 were coagulase-negative neomycin-sensitive staphylococci (CNS-NovS) and 338 were coagulase negative neomycin-resistant staphylococcus aureus (CNS-NovR) Other CNS 951 strains; (2) methicillin-resistant coagulase negative neomycin-sensitive staphylococci (MRC-NS-NovS) against ciprofloxacin, erythromycin, gentamicin, chloramphenicol, The rates of resistance to clindamycin, cotrimoxazole and tetracycline were 57.6%, 82.4%, 31.9%, 44.5%, 51.9%, 78.2% and 58.1%, respectively. (3) Methicillin- Susceptibility of Staphylococcus aureus (MSCNS-NovS) to cyclosporine Reclamation, chloramphenicol, sulfamethoxazole and tetracycline resistance rate than methicillin-sensitive Staphylococcus aureus is high, but still clinical Commonly used antibiotics ciprofloxacin, gentamicin, chloramphenicol, clindamycin have good sensitivity, resistance rates were 25.3%, 7.9%, 30.9%, 23.9%. Conclusion: It is necessary to strengthen the monitoring of CNS resistance.