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采用免疫组织化学方法研究了产后授乳和中断授乳的雌性大鼠下丘脑内促性腺激素释放激素(GnRH)阳性神经元和神经纤维的密度和染色反应的变化.在哺乳的第3天,将半数母鼠的仔鼠去除,中断授乳后1～4天下丘脑内侧隔核、视前内侧区和Broca斜角带内的GnRH阳性神经元胞体的反应强度明显高于继续授乳组.在正中隆起和终板血管器的GnRH阳性纤维和终末的密度和染色强度也比授乳组明显增加.结果表明:中断授乳的母鼠下丘脑内GnRH分泌神经元激素的合成和释放功能均明施增强,而哺乳对下丘脑内GnRH神经元的合成和释放激素的功能有显著的抑制作用.
Immunohistochemistry was used to study the changes of density and staining response of hypothalamus gonadotropin-releasing hormone (GnRH) -positive neurons and nerve fibers in postpartum lactating and interrupted lactating female rats. On day 3 of breastfeeding, half The mothers’ offspring were removed and the response intensity of GnRH-positive neurons in the medial hypothalamic medial septum, the anteromedial medial area and the Broca bevel were significantly higher than those in the continuing lactation group 1 to 4 days after interruption of lactation The density and staining intensity of GnRH-positive fibers and terminals in plate-vascular devices also increased significantly compared with that of lactation group.The results showed that the synthesis and release of GnRH-secreting neurons in the hypothalamus of females with interrupted lactation increased obviously, On the hypothalamus GnRH neurons synthesis and release of hormones have a significant inhibitory effect.