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(目的)观察活血化瘀中药配合放射疗法治疗鼻咽癌的疗效。(方法)自1995年6月至1997年12月将初治鼻咽癌患者135例先行血液流变学检测共11项,其中3项以上异常者随机分为两组:常规放疗组(对照组)46例,放疗加中药组(试验组)60例。两组放疗方法及剂量相同。试验组在放疗同时口服中药活化生津液6ml/日。疗前、疗后观察口腔粘膜反应,肿瘤消退情况,血液流变学变化及免疫功能改变,近期生存率。(结果)试验组治疗后血液流变学有5项指标明显改善(P<0.05)。试验组远处转移率3.31,对照组15.21(P<0.05)。试验组和对照组1年生存率分别98.3%及97.8%,2年生存率分别为95.4%及94.34%(P值均>0.05)。[结论]活血化瘀中药配合放射治疗鼻咽癌可以改善其血液高粘状态,改善微循环,减少远处转移。能否提高长期生存率尚待临床长期观察。
(Objective) To observe the curative effect of activating blood circulation and removing blood stasis medicine combined with radiotherapy on nasopharyngeal carcinoma. (Methods) From June 1995 to December 1997, 135 cases of newly diagnosed nasopharyngeal carcinoma patients had 11 first-line hemorheological tests, of which 3 or more were randomly divided into two groups: conventional radiotherapy group (control group ) 46 cases, radiotherapy and Chinese medicine group (experimental group) 60 cases. Radiotherapy methods and doses of the same two groups. The experimental group was treated with oral administration of Chinese herbal active fluid (6ml / day). Oral mucosal response, tumor regression, changes in hemorheology, changes in immune function, and recent survival were observed before and after treatment. (Results) There were 5 indexes of hemorheology in experimental group after treatment were significantly improved (P <0.05). The distant metastasis rate was 3.31 in the experimental group and 15.21 in the control group (P <0.05). The 1-year survival rates of the experimental and control groups were 98.3% and 97.8%, respectively, and the 2-year survival rates were 95.4% and 94.34%, respectively (all P> 0.05). [Conclusion] Activating blood circulation and removing blood stasis medicine combined with radiotherapy of nasopharyngeal carcinoma can improve its hyperviscous state, improve microcirculation and reduce distant metastasis. Whether to improve long-term survival remains to be observed in clinical long-term.