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闭经12周前在局麻或全麻下用负压吸引术作人流是有效和安全的,但可能发生与孕龄和麻醉有关的并发症,因此企图用药物来终止8周内的早孕以免作人流术。催产素性药物如前列腺素E和F阴道栓或肌注可引起90%以上孕妇流产,但由于胃肠道副反应发生率较高限制了其广泛应用。孕酮受体拮抗剂RU486能拮抗孕酮的生物学效应,使子宫朋活性增加,子宫出血,但不完全流产发生率高(约 30%),近来报告早孕时如以RU486加亚临床剂量的Sulproston(一种强效的PGE_2衍生物)合并用药,完全流产发生率较高。本文中作者比较了早孕妇女以RU486单用或与PG类似物阴道栓(16,16-双甲基-反-△_2-PGE_1)合用诱导流产的结果。研究包括45例闭经<56天的孕妇,所有对象经免疫学妊娠试验确诊妊娠,根据月经史、临床检查和盆腔超声波检查确定孕龄,所有对象均为单胎妊
Amenorrhoeic use of local anesthesia under local anesthesia or general anesthesia 12 weeks prior to ablation is effective and safe, but complications associated with gestational age and anesthesia may occur, so attempts to terminate the early pregnancy within 8 weeks Abortion. Oxytocin drugs such as prostaglandin E and F vaginal suppository or intramuscular injection can cause more than 90% of pregnant women abortion, but because of the high incidence of gastrointestinal side effects limit its wide range of applications. Progesterone receptor antagonist RU486 can antagonize the biological effects of progesterone, so that uterine friends increased activity, uterine bleeding, but the incidence of incomplete abortion (about 30%), recently reported early pregnancy as RU486 plus sub-clinical dose Sulproston, a potent PGE 2 derivative, is used in combination with a higher incidence of complete abortion. The authors compared the results of abortion induced by RU486 alone or in combination with PG analogue vaginal suppository (16,16-bis-methyl-trans-Δ-2-PGE_1) in early pregnant women. The study included 45 pregnant women <56 days of amenorrhea. All subjects were diagnosed with pregnancy by immunological pregnancy test. The gestational age was determined according to menstruation history, clinical examination and pelvic ultrasonography. All subjects were singleton pregnancy