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药物遗传学在教科书中几乎总被写成是一门研究少数几种先天性代谢病的静止学科。患这些一般罕见的单基因遗传病的病人通常表现为药物分布或反应紊乱,原因是他们体内与药物吸收、分布、代谢、分泌或受体作用直接有关的蛋白质发生了变异(见表)。这些病人具有对各种药物反应特别敏感的罕见的等位基因,因此,有几种药物对他们来说,即使是用大多数病人完全能耐受的剂量,也会引起中毒。象无过氧化酶症和非典型的血浆伪胆碱酯酶症(见表)这一类药物遗传病就可证明是某一位点上的基因与某一环境化学剂之间简单而单纯的相互作用所引起
Pharmacogenetics is almost always written in textbooks as a stationary discipline that studies a few innate metabolic diseases. Patients suffering from these rare and rare forms of single-gene inheritance usually show dislocation or disruption of the drug because of the variation in their body of proteins that are directly related to the absorption, distribution, metabolism, secretion or receptor function of the drug (see table). These patients have rare alleles that are particularly sensitive to various drug reactions and therefore several drugs can cause poisoning to them even at doses that are perfectly tolerated by most patients. Like non-peroxidase and atypical plasma pseudo-cholinesterase (see table), genetic diseases such as these drugs can prove that a site of a chemical and environmental agents between a simple and simple Interaction caused