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目的:观察麝香保心丸联合西药治疗顽固型心绞痛的有效性及安全性。方法:选取本院2014年6月—2015年6月收治的82例顽固型心绞痛患者为研究对象,采用随机数字表法分成2组,每组41例。对照组给予拜阿司匹林、辛伐他汀等常规西药治疗;观察组在对照组治疗方案的基础上给予麝香保心丸口服,每次2粒,每天3次。比较2组治疗总有效率及不良反应发生率情况;比较2组患者治疗前后心绞痛发作情况及C-反应蛋白(CRP)、D-二聚体、超氧化物歧化酶(SOD)、内皮素(ET)水平变化情况。结果:治疗4疗程后,治疗总有效率观察组85.4%,对照组63.4%,差异有统计学意义(P<0.05),观察组高于对照组。观察组口干、恶心、胃部胀满等不良反应发生率14.6%,对照组7.3%,差异无统计学意义(P>0.05)。治疗后,2组心绞痛发作情况改善,CRP、D-二聚体、ET等因子水平降低,SOD水平升高,且观察组各指标水平改善程度优于对照组,差异均有统计学意义(P<0.05)。结论:对于顽固型心绞痛患者,麝香保心丸联合西药治疗能够减轻血管壁炎症反应、清除氧自由基,疗效确切、安全性高。
Objective: To observe the effectiveness and safety of Shexiang Baoxin Pill combined with Western medicine in treating refractory angina pectoris. Methods: Totally 82 patients with refractory angina admitted in our hospital from June 2014 to June 2015 were selected and divided into two groups (n = 41 in each group) by random number table. The control group was treated with aspirin, simvastatin and other conventional western medicine. The observation group was given oral administration of Shexiang Baoxin Pills twice a day for 3 times daily on the basis of the control group. The total effective rate and incidence of adverse reactions in the two groups were compared. The incidences of angina pectoris, CRP, D-dimer, superoxide dismutase (SOD) and endothelin ET) level changes. Results: After 4 courses of treatment, the total effective rate was 85.4% in the observation group and 63.4% in the control group, the difference was statistically significant (P <0.05). The observation group was higher than the control group. In the observation group, the incidence of adverse reactions such as dry mouth, nausea and bloated stomach was 14.6% and that in the control group was 7.3%, with no significant difference (P> 0.05). After treatment, the incidence of angina pectoris was improved, the levels of CRP, D-dimer, ET and other factors were decreased and the level of SOD was increased, and the level of each index in the observation group was better than that of the control group (P <0.05). Conclusion: For patients with refractory angina pectoris, combined with Western medicine treatment of musk pill can reduce the inflammatory reaction of the blood vessel wall, scavenging oxygen free radicals, the exact effect, high safety.