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目的从循证医学的角度系统评价长期吸烟对时间肺活量(FVC,FEV1,FEV1/FVC,MMEF)及呼气峰流量(PEF)的影响。方法采用计算机检索(CBN)中国期刊全文数据库(CNKI)、万方数据资源系统、美国国立图书馆PUBMED检索系统关于吸烟对肺功能影响的论文,并辅以手工检索和其他检索,对纳入文献进行方法评价,经计算机Meta分析专用软件ReviewManager5.0对国内外1976～2009年间累计涉及11015人的33篇关于吸烟对肺功能影响的文献研究进行Meta分析。结果共纳入33个研究(11015人),分别对FVC,FEV1,FEV1/FVC,MMEF,PEF计算MD及95%CI,依影响因素大小顺序排序:FEV1/FVC-6.05(-6.23,-5.86),PEF-1.08(-1.13,-1.02),MMEF-0.89(-0.92,-0.86),FVC-0.41(-0.44,-0.38),FEV1-0.09(-0.10,-0.08)。结论长期吸烟对于FVC,FEV1,FEV1/FVC,MMEF及PEF均有显著影响,尤以FEV1/FVC为著;吸烟是肺功能下降的一个重要危险因素。
Objective To systematically evaluate the effects of long-term smoking on time vital capacity (FVC, FEV1, FEV1 / FVC, MMEF) and expiratory peak flow (PEF) from the perspective of evidence-based medicine. Methods The papers of CNKI, Wanfang Data Resource System and the National Library of China PUBMED retrieval system on the effect of smoking on pulmonary function were searched by computerized retrieval (CBN), and manual retrieval and other retrieval were supplemented. Methods Meta-analysis was conducted on the literature review of 33 articles on the effects of smoking on pulmonary function involving 11015 people at home and abroad from 1976 to 2009 by reviewing Meta-analysis software. RESULTS: A total of 33 studies (11,015) were enrolled in this study. MD and 95% CI were calculated for FVC, FEV1, FEV1 / FVC, MMEF and PEF respectively and were ranked in order of influencing factors: FEV1 / FVC- 6.05 (-6.23, -5.86) , PEF-1.08 (-1.13, -1.02), MMEF-0.89 (-0.92, -0.86), FVC-0.41 (-0.44, -0.38), FEV1-0.09 (-0.10, -0.08). Conclusion Long-term smoking has a significant effect on FVC, FEV1, FEV1 / FVC, MMEF and PEF, especially FEV1 / FVC. Smoking is an important risk factor for pulmonary function decline.