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前言为了寻找适合于外科手术的镇静剂,六十年代初人们开始对丁酰对氟苯类衍生物进行大量筛选,得到较符合临床镇静要求的氟哌啶。它是一种强效安定剂。经过多年临床使用也发现它的一些不良的副作用。人们试图寻找更好的化合物以改善氟呱啶不足之处。金声等首先合成一些5-烷基-5-对氟苯甲酰丙基巴比吐酸及硫代巴比吐酸。其中5-乙基-5-对氟苯甲酰丙基巴比吐酸(X=O,R=Et):有明显的镇静作用,动物实验效果与氟哌啶近似,优于鲁米那,
Preface In order to find a sedative suitable for surgery, people began to conduct a large number of screening of butyryl p-fluorobenzene derivatives in the early 1960s to obtain droperidol which is more suitable for clinical sedation. It is a potent stabilizer. After years of clinical use it has also found some of its undesirable side effects. People are trying to find better compounds to improve flupirin deficiency. Golden Voice first synthesized some 5-alkyl-5-p-fluorobenzoyl-base barbituric acid and thiobarbituric acid. Among them, 5-ethyl-5-p-fluorobenzoylobaclbacid (X = O, R = Et) had obvious sedative effect and the animal experiment effect was similar to that of haloperidol,