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Purpose The authors investigated whether serum basic fibroblast growth factor (b-FGF) can be used as a noninvasive marker of renal parenchymal damage (scarri ng) in cases of vesicoureteric reflux (VUR). Methods Serum levels of b-FGF were measured in 120 children with known grade III to gradeV VUR and 21 controlsusin g a standardenzyme-linked immunosorbent assay technique. Results Sixty-five ch ildren had grade IIIVUR, 39 had grade IV, and 16 had grade V. Renal scarring was seen in 43 children on radionuclide scanning. There were no significant differe nces between serum b-FGF levels for different grades of VUR without scarring an d controls. However, serum b-FGF levels were significantly higher in VUR patien ts with renal scarring than in patients with VUR without renal scarring (P < .0 01). Conclusions This report is the first to document serum b-FGF profiles in c hildren with VUR and renal scarring. The authors recommend measuring it as a sim ple, noninvasive marker of renal scarring in cases of VUR.
Purpose The authors investigation whether serum basic fibroblast growth factor (b-FGF) can be used as a noninvasive marker of renal parenchymal damage (scarri ng) in cases of vesicoureteric reflux (VUR). Methods Serum levels of b-FGF were measured in 120 children with known grade III to grade V VUR and 21 controlsusin ga standardenzyme-linked immunosorbent assay technique. Results Sixty-five ch ildren had grade IIIVUR, 39 had grade IV, and 16 had grade V. Renal scarring was seen in 43 children on radionuclide scanning . There were no significant differences in serum b-FGF levels for different grades of VUR without scarring an d controls. However, serum b-FGF levels were significantly higher in VUR patien ts with renal scarring than in patients with VUR without renal scarring ( P <.0 01). Conclusions This report is the first to document serum b-FGF profiles in c hildren with VUR and renal scarring. The authors recommend measuring it as a sim ple, noninvasive marker of renal scarring in cases of VUR.