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倾倒综合征是胃手术后并发症,它表现为餐后30分钟内发生的早期和餐后数小时发生的晚期倾倒综合征。据认为餐后高渗食物迅速进入小肠引起水电解质分泌、血浓缩及血内肠调节多肽、肠高血糖素、神经紧张素(neurotensin)、血管活性肠肽(VIP)增多与早期倾倒综合征有关;而餐后血糖浓度迅速上升所致的高胰岛素血症与低血糖引起的晚期倾倒综合征有关。人们发现在胰腺和肠内含生长抑素(SS)较多,它可抑制以上激素及小肠水电解质的分泌。为证实 SS对防止倾倒综合征是否有效,作者对6例胃手术后有倾倒综合征表现的患者,研究了 SS 对该综合征的疗效及对上述激素分泌的影响。结果显示全部患者口服50或100g 葡萄糖后15分钟都出现倾倒综合征的症状,持续30～60分钟。早期倾倒综合征的表现还伴有心动过速、红细胞压积升高及血糖升高。静滴 SS 后,5例患者症状改善,1例
Dumping syndrome is a post-gastric complication that manifests as early dumping syndrome occurring in early and postprandial hours within 30 minutes after meal. Postprandial hypertonic food is thought to rapidly enter the small intestine causing the secretion of water and electrolytes, which is associated with an increase in blood concentration of intestinal gut regulatory polypeptide, glucagon, neurotensin, and vasoactive intestinal peptide (VIP) ; And hyperinsulinism caused by the rapid rise of postprandial blood glucose concentration is associated with late dumping syndrome caused by hypoglycemia. It is found in the pancreas and intestine with somatostatin (SS) more, it can inhibit the secretion of more than the above hormones and small intestine water electrolytes. To confirm that SS is effective in preventing dumping syndrome, we investigated the efficacy of SS in the syndrome and its effect on hormone secretion in 6 patients with dumping syndrome after gastric surgery. The results showed that all patients had symptoms of dumping syndrome 15 minutes after oral administration of 50 or 100 g of glucose for 30 to 60 minutes. The signs of early dumping syndrome are associated with tachycardia, elevated hematocrit and elevated blood sugar. After intravenous infusion of SS, the symptoms of 5 patients improved, 1 case