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用静电喷雾法制备了粒径窄分布的甘氨酸乙酯-苯丙氨酸乙酯取代聚膦腈的微球.主要探讨了溶剂、溶液浓度、流速、喷射电压及接收距离对微球形貌和粒径的影响.微球的表面形貌与溶剂性质和聚合物溶液浓度密切相关,微球粒径受聚合物溶液流速的影响比较显著,随流速增大粒径呈单调上升趋势.结果显示对于[η]=0.1 dL/g的(甘氨酸乙酯)0.3(苯丙氨酸乙酯)0.7取代聚膦腈,以0.25 g/mL的四氢呋喃溶液进行静电喷雾,可获得粒径分布窄(1~2μm)且近球形的微粒,其工艺条件可进一步用于载药聚膦腈微球的制备和控制释放研究.
The microspheres with narrow distribution of glycine ethyl ester-phenylalanine ethyl ester substituted polyphosphazene were prepared by electrostatic spraying method.The influences of solvent, solution concentration, flow rate, jet voltage and receiving distance on the microspheres morphology and The size of the microspheres surface morphology and solvent properties and the concentration of the polymer solution is closely related to the diameter of the microspheres affected by the flow rate of the polymer solution is more significant with the flow rate increased monotonous upward trend in particle size.The results show that (η) = 0.1 dL / g (glycine ethyl ester) 0.3 (phenylalanine ethyl ester) 0.7 instead of polyphosphazene, and 0.25 g / mL of tetrahydrofuran solution were electrosprayed to obtain a narrow particle size distribution (1 ~ 2μm) and nearly spherical particles, the process conditions can be further used for the preparation of drug-loaded polyphosphazene microspheres and controlled release studies.