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1985年Epler氏从2500例开胸肺活检的病例中,发现一般诊断为普通型间质性肺炎(UIP)的患者,除肺泡炎之外伴有闭塞性细支气管炎(BO)与机化性肺炎(OP),且与一般UIP的临床表现不同,预后较好,故命名为闭塞性细支气管机化性肺炎(BOOP)。但也有学者认为这些病例应属于BO伴弥漫性肺泡损害(BIP)或与其他机化性肺炎相类似的疾病。病因。①有害气体(NO_2、SO_2、HCl等)吸入;②各种感染(支原体肺炎、军团菌肺炎)等;③胶原病(慢性风湿性关节炎等);④其他如自身骨髓移植后。而更多的是原因不明的所谓“特发性”。1988年日本全国调查仅发现30例,其中特发性21例,胶原病6例(RA4例,皮肌炎1例,Behcet病1例),慢性甲状腺炎2例,酒精性肝硬化1例。
In 1985, from 2,500 open lung biopsy cases, Epler found that patients with generalized interstitial pneumonia (UIP) who were commonly diagnosed as having generalized interstitial pneumonitis (UIP) were associated with bronchiolitis obliterans (BO) and organitization Pneumonia (OP), and the clinical manifestations of the general UIP is different, the prognosis is good, so named for obliterative bronchi-pervasive pneumonia (BOOP). However, some scholars believe that these cases should belong to BO with diffuse alveolar damage (BIP) or other similar diseases and other organic pneumonia. Etiology. ① harmful gases (NO_2, SO_2, HCl, etc.) inhalation; ② a variety of infections (Mycoplasma pneumonia, Legionella pneumonia) and so on; ③ collagen disease (chronic rheumatoid arthritis, etc.); ④ other such as their own bone marrow transplantation. And more is the so-called “idiopathic” of unknown cause. In 1988, only 30 cases were found in Japanese national survey, including 21 idiopathic cases, 6 cases of collagen disease (4 cases of RA, 1 case of dermatomyositis, 1 case of Behcet disease), 2 cases of chronic thyroiditis and 1 case of alcoholic cirrhosis.