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表皮生长因子(epidermal growth factor,EGF)通过与细胞膜上表皮生长因子受体((epidermal growthfactor receptor,EGFR)特异性结合,引起靶细胞内一系列生物效应,控制着细胞的代谢、生长、分化和癌变。近年来,一些研究表明某些胃癌细胞中有EGF及其受体过度表达,对胃癌的发生和发展具有一定作用,故EGF及其受体与胃癌关系的研究日益受到人们的关注和重视,作者就近年来在这方面的研究进展综述如下。1 1%#11EGF及其受体的生物学特性EGF是一个由53个氨基酸组成的多肽类激素,主要由领下腺、十二指肠Brunner腺和肾脏等合成,也存在于胰腺、甲状腺和空肠等处,其合成受胸腺素的调节,EGF以外分泌形式分泌到唾液、胃液、肠液、胆汁、血液及乳汁中。EGF主要促进细胞增殖,是一广谱促分裂剂,能促进细胞内DNA、RNA和蛋白质等的合成,加速上皮细胞的增殖和分化。EGF随唾液及十二指肠液进入胃肠道,对维持胃肠道上皮的完整性起了重要作用。此外,还有促进K~+的运转和H~+-Na~+交换,激活糖酵解和糖的异生,增加前列腺素的合成和释放,调节骨和钙的代谢等功能。
Epidermal growth factor (EGF) specifically binds to the epidermal growth factor receptor (EGFR) on the cell membrane, causing a series of biological effects in the target cell, controlling the metabolism, growth, differentiation and In recent years, some studies have shown that some gastric cancer cells have excessive expression of EGF and its receptors, which have a certain role in the occurrence and development of gastric cancer, so the study of the relationship between EGF and its receptors and gastric cancer has attracted increasing attention and attention. The authors summarize the research progress in this area in recent years as follows: 1 1% #11 Biological characteristics of EGF and its receptors EGF is a 53-amino acid polypeptide hormone mainly composed of the submandibular gland and the duodenum Brunner. Syntheses such as glands and kidneys also exist in the pancreas, thyroid and jejunum, etc. Its synthesis is regulated by thymosin, which secretes into the saliva, gastric juice, intestinal fluid, bile, blood and milk, and EGF mainly promotes cell proliferation. It is a broad-spectrum mitogen that can promote the synthesis of DNA, RNA, and protein in cells and accelerate the proliferation and differentiation of epithelial cells.EGF with saliva and duodenal juice Entering the gastrointestinal tract plays an important role in maintaining the integrity of the epithelium of the gastrointestinal tract.In addition, it also promotes the operation of K~+ and the exchange of H~+-Na~+, activates glycolysis and variability of sugar, and increases. The synthesis and release of prostaglandins regulate bone and calcium metabolism and other functions.