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目的探讨血同型半胱氨酸(Hcy)与糖尿病肾病的关系。方法血同型半胱氨酸由荧光偏振免疫分析法测定,尿白蛋白排泄率由放射免疫法测定。结果临床糖尿病肾病组、早期糖尿病肾病组、无糖尿病肾病组及对照组血同型半胱氨酸(μmol/L)分别为20.45±3.56、16.56±4.12、13.12±4.48、8.72±3.54。临床糖尿病肾病组、早期糖尿病肾病组、无糖尿病肾病组分别与对照组比较差异均有统计学意义(P<0.01);临床糖尿病肾病组、早期糖尿病肾病组分别与无糖尿病组比较差异均有统计学意义(P<0.01);临床糖尿病肾病组与早期糖尿病肾病组比较差异有统计学意义(P<0.01);同时各糖尿病组血同型半胱氨酸与尿白蛋白排泄率呈正相关。结论高同型半胱氨酸参与2型糖尿病肾病致病的过程,并且可能是2型糖尿病肾病发病的一种独立危险因子。
Objective To investigate the relationship between blood homocysteine (Hcy) and diabetic nephropathy. Methods Blood homocysteine was determined by fluorescence polarization immunoassay, urinary albumin excretion rate was determined by radioimmunoassay. Results The levels of homocysteine (μmol / L) in clinical diabetic nephropathy group, early diabetic nephropathy group, non-diabetic nephropathy group and control group were 20.45 ± 3.56,16.56 ± 4.12,13.12 ± 4.48,8.72 ± 3.54 respectively. There were significant differences between clinical diabetic nephropathy group, early diabetic nephropathy group and non-diabetic nephropathy group and the control group (P <0.01). There were statistical differences between clinical diabetic nephropathy group and early diabetic nephropathy group and non-diabetic group (P <0.01). There was significant difference between clinical diabetic nephropathy group and early diabetic nephropathy group (P <0.01). At the same time, the blood homocysteine and urinary albumin excretion rate were positively correlated in each diabetic group. Conclusion Homocysteine is involved in the pathogenesis of type 2 diabetic nephropathy and may be an independent risk factor for type 2 diabetic nephropathy.