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目的探讨血清尿酸水平与冠心病(CHD)发病的相关性。方法收集214例CHD患者和200例健康对照者资料,检测血尿酸(SUA)、空腹血糖(FPG)和血脂等指标,记录年龄、性别、血压、身高、体重,计算体质指数(BMI)。结果与非CHD组比较,年龄、性别、血压、FPG、血脂(TC、TG、LDL-C和HDL-C)、BMI、SUA在CHD组的分布差异具有统计学意义,P<0.05。Logistic回归分析结果表明性别、糖尿病、高血压、CHD家族史为CHD发生的独立危险因素。高血压、高血糖、TG≥1.7 mmol/L、BMI、SUA≥416μmol/L在单纯CHD组和CHD-MS组中的分布差异具有统计学意义,P<0.05。结论SUA水平是CHD发病的危险因素;但不构成独立危险因素;有代谢综合征的CHD患者血清尿酸水平更易升高。
Objective To investigate the relationship between serum uric acid level and the incidence of coronary heart disease (CHD). Methods The data of 214 CHD patients and 200 healthy controls were collected. SUA, FPG and serum lipid levels were measured. Age, sex, blood pressure, height, weight and body mass index (BMI) were calculated. Results The distribution of age, gender, blood pressure, FPG, blood lipids (TC, TG, LDL-C and HDL-C), BMI and SUA in CHD group were significantly different (P <0.05). Logistic regression analysis showed that gender, diabetes, hypertension and family history of CHD were independent risk factors for CHD. The distribution of hypertension, hyperglycemia, TG≥1.7mmol / L, BMI, SUA≥416μmol / L in CHD group and CHD-MS group were statistically significant, P <0.05. Conclusions SUA level is a risk factor for CHD but not an independent risk factor. Serum uric acid level is more likely to be elevated in CHD patients with metabolic syndrome.