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目的:观察参芪地黄散对急性肾损伤(acute kidney injury,AKI)恢复期患者治疗疗效以及肾功能的影响.方法:选取2014年3月～ 2016年4月我院收治AKI恢复期患者188例,依据随机数字表法随机分为观察组(94例)和对照组(94例),对照组给予对症治疗以及激素治疗,观察组在对照组基础上给予参芪地黄散治疗.两组连续治疗3个月后,观察两组治疗疗效、中医证候积分、肾功能变化以及不良反应.结果:观察组总有效率达86.17％,显著高于对照组总有效率64.89％ (P＜0.05);治疗后,观察组中医证候总积分显著低于对照组(P＜0.05);治疗后观察组内生肌酐清除率(Ccr)显著高于对照组(P＜0.05),尿蛋白、尿素氮(BUN)和血肌酐(Scr)水平显著低于对照组(P＜0.05);观察组总不良反应率显著低于对照组(P＜0.05).结论:参芪地黄散能有效改善AKI恢复期患者临床症状,促进患者肾功能恢复,较为安全有效.“,”Objective:To investigate the effect of Shenqi Dihuang Powder on renal function in patients with acute kidney injury (AKI) in convalescent period.Methods:A total of 188patients with AKI in convalescent period in our hospital who were admitted between March 2014and April 2016were randomly divided into observation group (n=94) and controlled group (n=94) by the random number table method.The controlled group was given symptomatic treatment and hormone therapy.On the basis,the observation group were treated with Shenqi Dihuang Powder.After 3months of treatment,the efficacy,TCM syndrome score,changes of renal function and adverse reactions in the two groups were observed.Results:The total effective rate was significantly higher in the observation group than the controlled group (86.17％ vs 64.89％) (P＜ 0.05).After treatment,the total score of TCM syndrome in the observation group (4.06±1.32) was significantly lower than that in the controlled group (P＜0.05).After treatment,the creatinine clearance rate (Ccr) in the observation group was increased to (84.32±8.27) ml/min which was significantly higher than that in the controlled group (P＜0.05).The urine protein,blood urea nitrogen (BUN) and serum creatinine (Scr) levels were reduced to (0.73±0.27) g/24h,(5.20±2.14) mmol/L and (95.32±21.47) mol/L,significantly lower than those in the controlled group (P＜0.05).The total incidence of adverse reactions was significantly lower in the observation group than the controlled group (6.38％ vs 18.08％) (P＜0.05).Conclusion:Shenqi Dihuang Powder can effectively relieve the clinical symptoms of patients with AKI in convalescent period,and promote the recovery of renal function.It is safe and effective.