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作者报道35例何杰金氏病(淋巴网细胞瘤)患者伴有严重且持续的周围血相中红细胞、白细胞、血小板中一种或三种都减少。临床未发现脾肿大,但在任何治疗中,上述情况颇为常见。多数患者在应用标准同位素检查,显示细胞破坏增多(红细胞或血小板),尚有一部分患者显示铁代谢紊乱。35例行脾切除术,23例发现脾脏受累,12例尚未受累,但其中7例红细胞破坏增多(表现为铁聚集),或血小板破坏。术后28例周围血相完全纠正,平均完全缓解期为24个月,同时对于治疗增强了耐力。术后感染率并不突出。作者结论为晚期何杰金氏病患者在虽未发现脾脏受累的情况下,脾切除可增强患者对治疗的耐力。
The authors report that 35 patients with Hodgkin’s disease (lymphoblastoma) had severe and persistent peripheral blood red blood cells, white blood cells, and one or all three of the platelets decreased. No splenomegaly was found clinically, but this is quite common in any treatment. Most patients in the application of standard isotope examination, showing increased cell destruction (red blood cells or platelets), there are still some patients showed iron metabolism disorders. Splenectomy was performed in 35 cases, spleen involvement was found in 23 cases, and 12 cases were not involved. However, 7 cases showed increased erythrocyte destruction (manifested as iron accumulation) or platelet destruction. Peripheral blood was completely corrected in 28 cases after operation, with a mean complete remission of 24 months and increased endurance for treatment. Postoperative infection rate is not prominent. The authors conclude that splenectomy may enhance patient endurance to treatment despite the absence of splenic involvement in patients with Hodgkin’s disease.