四环素致动脉粥样斑块光敏作用的研究

• 出 处: 同济医科大学学报
• 发表日期: 1990年04期
• 关键词: 四环素 粥样斑块 动脉 准分子激光消融 光敏作用 准分子激光 紫外光吸收 光吸收特性 光谱分析技术 家兔模型

作者为提高准分子激光消融动脉粥样斑块的敏感性与特异性,采用荧光和光谱分析技术研究四环素在动脉粥样斑块中较特异性结合及四环素的光吸收特性。结果:家兔模型中证明,四环素在离体或在体情况下均能迅速而又较特异地结合于动脉粥样斑块中;四环素对230～400 nm波长范围紫外光吸收明显,并在270和358 nm处形成最大吸收峰。用波长为308 nm的准分子激光(50 mJ×100次)照射经四环素处理和未经处

To improve the sensitivity and specificity of excimer laser ablation of atherosclerotic plaques, the authors used fluorescence and spectral analysis techniques to study the more specific binding of tetracycline and the light absorption properties of tetracycline in atherosclerotic plaques. RESULTS: The rabbit model demonstrated that tetracycline could rapidly and specifically bind to atherosclerotic plaque in vitro or in vivo. Tetracycline absorbs ultraviolet light in the wavelength range of 230-400 nm significantly, and at 270 And the maximum absorption peak at 358 nm. Excimer laser irradiation (50 mJ × 100) with a wavelength of 308 nm was performed by tetracycline treatment and without treatment