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目的探讨老年冠心病合并类风湿关节炎(RA)患者胃饥饿素(Ghrelin)/肥胖抑制素(obestatin)比值变化及临床意义。方法收集冠心病患者117例作为研究对象,根据是否合并RA分为冠心病RA组(n=49)和单纯冠心病组(n=68),选择同期健康体检者50例作为对照组。采用酶联免疫法(ELASA)测定血清Ghrelin、obestatin水平。根据冠脉造影结果采用Gensini积分评估冠脉病变程度。结果冠心病RA组、单纯冠心病组患者的Ghrelin/obestatin比值显著低于对照组,冠心病RA组患者的Ghrelin/obestatin比值明显低于单纯冠心病组,差异均有统计学意义(P<0.05);冠心病RA组患者的Gensini积分明显高于单纯冠心病组,差异有统计学意义(P<0.05)。冠心病RA组患者的Ghrelin/obestatin比值与Gensini积分呈负相关(r=-0.56,P<0.05)。结论老年冠心病合并RA患者的Ghrelin/obestatin比值与冠状动脉病变程度密切相关。Ghrelin/obestatin比值在预测冠心病合并RA中有一定的辅助参考价值。
Objective To investigate the changes of Ghrelin / obestatin ratio in elderly patients with coronary heart disease and rheumatoid arthritis (RA) and its clinical significance. Methods A total of 117 patients with coronary heart disease were enrolled in this study. Fifty patients with coronary heart disease (n = 49) and simple coronary heart disease (n = 68) were enrolled in the study. Serum levels of ghrelin and obestatin were determined by enzyme-linked immunosorbent assay (ELASA). According to coronary angiography results using Gensini score coronary artery disease. Results The Ghrelin / obestatin ratio in patients with coronary heart disease RA and simple coronary heart disease was significantly lower than that in the control group. The Ghrelin / obestatin ratio in patients with coronary artery disease RA was significantly lower than that in patients with coronary heart disease (P <0.05) ). The Gensini score in patients with coronary heart disease RA was significantly higher than that in patients with coronary heart disease alone (P <0.05). The Ghrelin / obestatin ratio in patients with coronary heart disease RA was negatively correlated with Gensini score (r = -0.56, P <0.05). Conclusion The Ghrelin / obestatin ratio in elderly patients with coronary heart disease and RA is closely related to the severity of coronary artery disease. Ghrelin / obestatin ratio in the prediction of coronary heart disease with RA has some auxiliary reference value.