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目的探讨促性腺激素释放激素激动剂（GnRH－a）在多翼卵巢综合征（PCOS）诱导排卵中的作用。方法对8例用克罗米芬无反应的PCOS患者，采用国产GnRH－a长期脱敏方案，达到垂体抑制后联合用国产HMG－HCG促排卵，共治疗17个周期。结果14个周期排卵（排卵率为82．4％），6例妊娠（周期妊娠率35．3％，累计妊娠率75．0％），5例足月活产（4例单胎，1例双胎），1例流产。1个周期出现重度卵巢过度刺激综合征（OHSS），2个周期出现中度OHSS，均为妊娠周期。结论对PCOS患者采用GnRH－a长期脱敏联合HMG可获得较高妊娠率，提高活产率，降低流产率，并减少严重OHSS的发生。
Objective To investigate the effect of gonadotropin-releasing hormone agonist (GnRH-a) on ovulation induced by polyvary ovary syndrome (PCOS). Methods Eight PCOS patients who did not respond to clomiphene were treated with domestic GnRH-a long-term desensitization scheme to achieve pituitary suppression combined with domestic HMG-HCG ovulation induction for a total of 17 cycles. Results 14 cycles of ovulation (ovulation rate was 82.4%), 6 cases of pregnancy (cycle pregnancy rate 35.3%, cumulative pregnancy rate 75.0%), 5 cases of full-term live births (4 cases of singletons, 1 case Twins), 1 case of abortion. One cycle of severe ovarian hyperstimulation syndrome (OHSS), two cycles of moderate OHSS, are the pregnancy cycle. Conclusion Long-term desensitization combined with HMG with GnRH-a in PCOS patients can achieve higher pregnancy rate, increase live birth rate, reduce abortion rate and reduce the incidence of severe OHSS.