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非类固醇抗炎药(NSAID)的应用可引起胃溃疡、胃十二指肠溃疡的并发症和死亡,这已是无可辩驳的事实。已有的报道提示,引起胃溃疡的相对危险性(relative risk,RR)为4.7～5.0。十二指肠溃疡的RR是1.1,上消化道出血由于胃和十二指肠溃疡所致的RR分别为2.8和2.7,胃溃疡所致死亡的危险性为4.2,十二指肠溃疡为7.9。死亡并非由于溃疡本身,而是由于溃疡所致的并发症。迄今为止,能够预测发生病变的危险因素还很局限。流行病学和发病原因发病类型药物使用指南一般建议以往有溃疡病史及消化不良者应避免使用NSAIDs,但此种建议是否确有依据尚属可疑。临床上常
The use of non-steroidal anti-inflammatory drugs (NSAIDs) can cause gastric ulcer, complications and death of gastroduodenal ulcer, which is an irrefutable fact. Some reports suggest that the relative risk (RR) of gastric ulcer is 4.7 ~ 5.0. RR of duodenal ulcer was 1.1, upper gastrointestinal bleeding due to gastric and duodenal ulcer caused by RR were 2.8 and 2.7, respectively, the risk of gastric ulcer death was 4.2, duodenal ulcer was 7.9 . Death is not due to the ulcer itself but to the complication caused by the ulcer. So far, the risk factors for predicting the occurrence of the disease remain limited. Epidemiology and Causes of Disease Types of Disease Guideline for Drug Use General Recommendations Formerly, patients with a history of ulcers and dyspepsia should avoid using NSAIDs, but it is doubtful whether such advice is valid. Clinically normal