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用卫氏并殖吸虫囊蚴感染Wister大白鼠,在感染后动态观察其外周血白细胞,经166～174天解剖观察。结果表明:①感染鼠的脾重及脾指数与正常鼠比较无明显差异(P>0.05);②外周血嗜酸性白细胞(EOS)的绝对值在吡喹酮治疗后显增;③T淋巴细胞(TL)的增高有非常显著意义(P<0.01);④在肺组织中的虫卵引起大量巨噬细胞反应,在皮下组织中的虫卵引起结核样结节。作者认为大鼠P.w.病的免疫反应除了体液免疫外,还可能存在着细胞免疫及抗体与细胞协同作用的免疫反应。
Wister rats were infected with Paragonimus westermanii metacercariae and their peripheral blood leukocytes were observed dynamically after infection. Anatomical observation was performed for 166 to 174 days. The results showed that: ① The spleen weight and spleen index of infected mice showed no significant difference compared with normal mice (P> 0.05); ② The absolute value of peripheral blood eosinophils (EOS) increased significantly after praziquantel treatment; ③T lymphocytes TL) was significantly increased (P <0.01). ④ The eggs in the lung tissue caused a large number of macrophages to react, and the eggs in the subcutaneous tissue caused nodular nodules. The authors believe that in addition to humoral immunity, immune responses to P. w. Disease in rats may also present cellular immunity and an immune response that synergizes with the antibody.