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目的 :研究粉防己碱对转化生长因子 β促瘢痕胶原基质收缩效应的作用。 方法 :将瘢痕成纤维细胞、胶原基质和转化生长因子 β共同构成体外瘢痕实验模型 ,观察粉防己碱对其收缩指数的影响。结果 :粉防己碱对转化生长因子β促瘢痕胶原基质收缩具有阻断作用 ,并呈剂量依赖关系。结论 :这一效应可能是粉防己碱抗瘢痕纤维化的机制之一。
Objective: To study the effect of tetrandrine on contractile effects of transforming growth factor β on scar collagen matrix. METHODS: Scar fibroblasts, collagen matrix and transforming growth factor β were combined to form an in vitro scar model. The effect of tetrandrine on its contraction index was observed. RESULTS : Tetrandrine had a blocking effect on TGF-β-induced scar-induced collagen matrix contraction in a dose-dependent manner. Conclusion: This effect may be one of the mechanisms of tetrandrine anti-scarring fibrosis.