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目的:通过调查糖尿病患者乙型肝炎病毒(HBV)的携带率,阐明糖尿病发生是否与HBV感染有关,并观察糖尿病合并HBV感染时是否加重对肝功能的损害。方法:用ELISA方法检测533例2型糖糖尿病患者和1440例普通人群乙型肝炎表面抗原(HBsAg)以及HBV其他血清学标志,同时常规测定肝功能和血糖等。结果:2型糖尿病HBsAg阳性24例,阳性率4.50%,普通人群HBsAg阳性70例,阳性率4.86%,两组间阳性率差异无统计学意义(x2=0.110,P=0.740)。糖尿病患者感染HBV后的抗体应答与普通人群相似。糖尿病合并HBV感染者与无糖尿病HBV感染者的肝功能异常差异无统计学意义。糖尿病患者中83例(16.3%)谷氨酰转肽酶升高,在肝功能异常指标中最常见,这与HBV感染后丙氨酸转氨酶升高为主不同。结论:糖尿病发生与HBV感染无关,糖尿病合并HBV感染时不加重对肝脏的损害。
Objective: To investigate whether the incidence of diabetes is related to HBV infection by investigating the carrier rate of Hepatitis B virus (HBV) in diabetic patients and to observe whether the aggravating of hepatic dysfunction in diabetic patients complicated with HBV infection. Methods: HBsAg and other serological markers of HBV in 533 type 2 diabetes mellitus patients and 1440 ordinary people were detected by ELISA, and liver function and blood glucose were measured routinely. Results: The positive rate of HBsAg in type 2 diabetes mellitus was 24%, the positive rate was 4.50%. The positive rate of HBsAg in the general population was 70%. The positive rate was 4.86%. There was no significant difference between the two groups (χ2 = 0.110, P = 0.740). Antibody responses in diabetics infected with HBV are similar to those in the general population. There was no significant difference in abnormal liver function between diabetic patients with HBV infection and non-diabetic patients with HBV infection. Eighty-three patients (16.3%) with elevated glutamyl transpeptidase were the most common markers of abnormal liver function in patients with diabetes mellitus, which is different from the increase of alanine aminotransferase after HBV infection. Conclusion: The incidence of diabetes has nothing to do with the infection of HBV, and the infection of diabetes mellitus does not aggravate the damage to the liver.