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AIM:There is still no accepted conclusion regarding theclinical features and related risk factors of patients with fattyliver.The large-scale clinical studies have not carried outyet in Guangzhou area.The aim of the present study was toinvestigate the clinical features and related risk factors ofpatients with fatty liver in Guangzhou area.METHODS:A total of 413 cases with fatty liver were enrolledin the study from January 1998 to May 2002.Retrospectivecase-control study was used to evaluate the clinical featuresand related risk factors of fatty liver with logistic regression.RESULTS:Obesity(OR:21.204),alcohol abuse(OR:18.601),type 2 diabetes mellitus(OR:4.461),serum triglyceride(TG)(OR:3.916),serum low-density lipoprotein cholesterol(LDL-C)(OR:1.840)and fasting plasma glucose(FPG)(OR:1.535)were positively correlated to the formation of the fatty liver.The levels of serum alanine aminotransferase(ALT)and gamma-glutamyltransferase(GGT)increased mildly in the patients withfatty liver and were often less than 2-fold of the normal limit.The higher abnormalities of aspartate aminotransferase(AST)levels(42.9%)with AST/ALT more than 2(17.9%)were foundin patients with alcoholic fatty liver(AFL)than those withnonalcoholic fatty liver(NAFL)(16.9% and 5.0% respectively).The elevation of serum TG,cholesterol(CHOL),LDL-C wasmore common in patients with NAFL than with AFL.CONCLUSION:Obesity,alcohol abuse,type 2 diabetesmellitus and hyperlipidemia may be independent risk factorsof fatty liver.The mildly abnormal hepatic functions can befound in patients with fatty liver.More obvious damages ofliver function with AST/ALT usually more than 2 were notedin patients with AFL.
AIM: There is still no accepted terminology on theclinical features and related risk factors of patients with fattyliver.The large-scale clinical studies have not carried outyet in Guangzhou area. The aim of the present study was to investigate the clinical features and related risk factors ofpatients with fatty liver in Guangzhou area. METHODS: A total of 413 cases with fatty liver were enrolled in the study from January 1998 to May 2002. Retrospectivecase-control study was used to evaluate the clinical features and related risk factors of fatty liver with logistic regression .RESULTS (OR: 21.204), alcohol abuse (OR: 18.601), type 2 diabetes mellitus (OR: 4.461), serum triglyceride (TG) (OR: 3.916), serum low-density lipoprotein cholesterol : 1.840) and fasting plasma glucose (FPG) (OR: 1.535) were positively correlated to the formation of the fatty liver. The levels of serum alanine aminotransferase (ALT) and gamma- glutamyltransferase (GGT) increased mildly in the patients with fatty liver andwere often less than 2-fold of the normal limit.The higher abnormalities of aspartate aminotransferase (AST) levels (42.9%) with AST / ALT more than 2 (17.9%) were foundin patients with alcoholic fatty liver (AFL) than those with nonalcoholic The elevation of serum TG, cholesterol (CHOL), LDL-C was more common in patients with NAFL than with AFL.CONCLUSION: Obesity, alcohol abuse, type 2 diabetes mellitus and hyperlipidemia (NAFL) (16.9% and 5.0% respectively) may be independent risk factors of fatty liver. The mildly abnormal hepatic functions can be in patients with fatty liver. More obvious damages of liver function.