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目的:探讨脑梗死(CI)后早发性癫癎发作(EES)的临床特点。方法:对2643例确诊为CI患者的临床资料进行回顾性研究。结果:CI后EES的发生率为4.58%,女性高于男性(P<0.05);婴幼儿及未成年人高于成年人(P<0.01)和老年人(P<0.01);累及皮质的发生率高于未累及皮质的(P<0.01);EES作为CI首发症状者占49.59%,24h内出现者占76.03%,1周内出现者占94.21%,仅有5.79%在第2周出现;局灶性发作占65.29%,全面性发作占34.71%;给予AEDs治疗发作均可控制,伴有EES的患者病死率高于不伴有者(P<0.05)。结论:CI后EES较为常见,女性多于男性,未成年人的发生率高于成年人及老年人,与梗死部位有关,以局灶性发作为主,抗癫癎治疗有效,临床预后较差。
Objective: To investigate the clinical features of early onset epileptic seizures (EES) after cerebral infarction (CI). Methods: The clinical data of 2643 patients diagnosed as CI were retrospectively studied. Results: The incidence of EES in CI was 4.58%, higher in female than in male (P <0.05), higher in infants and young adults than in adults (P <0.01) and elderly (P <0.01) (P <0.01). The incidence of EES as the first symptom of CI was 49.59%, 76.03% within 24 h, 94.21% within 1 week and only 5.79% in the second week. Focal seizures accounted for 65.29%, comprehensive seizures accounted for 34.71%; given AEDs treatment seizures can be controlled, with EES patients mortality was higher than non-associated (P <0.05). Conclusion: The EES is more common in CI patients than in men. The incidence of minors is higher than that of adults and seniors. It is related to the infarction site. The focal episodes are mainly epilepsy treatment, and the clinical prognosis is poor .