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药物在保存过程中一般的均应注意密閉条件。密閉环境对药物的風化、潮解等物理变化来讲是有很大意义的,若不注意药物的这些性質就能影响制剂的含量,如某药房配制50%溴化鈉溶液时,定量分析結果,一般只含有45%左右,这是因为溴化鈉在保存时吸收了一部分水(6%左右)的緣故。根据这种情况我們可以採用兩种方法解决。药房中有条件作定量分析的,可以用銀量法(莫尔氏法)將配好的濃溶液定量(1毫克NaBr相当0.1 N AgNO_3 0.0972毫外,取50%NaBr 0.1毫升需0.1 N AgNO_3 4.86毫升)。以后再按其百分含量加入NaBr調整至所需的百分濃度。如沒有化学分析设备的,可將原料药品干燥至恆重,含水量应不超过药典規定(如溴化鈉所含水分不得超过1.5%),如超过时可經換算求出样品实际百分含量,公式如下:
Drugs in the preservation process should pay attention to the general closed conditions. Closed environment for the chemical weathering, deliquescence and other physical changes in terms of great significance, if you do not pay attention to these properties of the drug can affect the content of preparations, such as a pharmacy preparation of 50% sodium bromide solution, the quantitative analysis of the results, Generally only about 45%, this is because sodium bromide in the preservation of the absorption of a part of the water (about 6%) sake. According to this situation we can use two methods to solve. Pharmacy conditions for quantitative analysis, you can use the silver method (Moir’s method) will be equipped with a good concentrated solution (1 mg NaBr 0.1 N AgNO_3 0.0972 milliliters, take 50% NaBr 0.1 ml 0.1 N AgNO_3 4.86 Ml). Later according to its percentage by adding NaBr adjusted to the desired percentage concentration. If there is no chemical analysis equipment, raw materials can be dried to a constant weight, the water content should not exceed Pharmacopoeia (such as sodium bromide contained in the water shall not exceed 1.5%), if more than can be obtained by calculating the actual sample percentage , The formula is as follows: