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目的:探讨补肾中药组方金锁二仙饮对雄性实验性肾虚小鼠雄激素的调节作用。方法:60只雄性小鼠,随机分为正常组,模型组,阳性药物组,金锁二仙饮高剂量组、中剂量组、低剂量组,各10只。采用“恐伤肾”方法造模7天后,以相应的药物灌胃14天,称重,摘除眼球取血,放射免疫法测定血清T、FSH及LH,处死动物摘取小鼠前列腺、精囊腺、左侧睾丸等相关脏器,分析天平称重。结果:金锁二仙饮组小鼠血清T、FSH、LH水平较模型组增高,小鼠睾丸、前列腺+精囊腺重量及体重亦较模型组增高,均有统计学意义(P<0.O5);其中金锁二仙饮高剂量组前列腺+精囊腺重量较正常组与模型组均高,有统计学意义(P<0.05)。结论:金锁二仙饮能提高肾虚模型小鼠血清T水平,增加附性腺(前列腺+精囊腺)重量及实验小鼠体重。
Objective: To investigate the effect of Prescriptions of Tonifying Kidney and Prescription Decoction on Regulating Androgen in Mice with Experimental Kidney Deficiency. Methods: Sixty male mice were randomly divided into normal group, model group, positive drug group, Jinlu Erxianyin high dose group, middle dose group and low dose group. After 7 days, the rats were weighed and the eyeballs were taken out. The serum T, FSH and LH were measured by radioimmunoassay. The mice were sacrificed and the prostate was removed. Seminal vesicles, the left testis and other related organs, analytical balance weighing. Results: The levels of serum T, FSH and LH in Jinshou Erxian Drink group were higher than those in model group, and the weight and weight of testis, prostate + seminal vesicle in mice were also higher than those in model group (P <0.05) ). The weight of the prostate + seminal vesicle in the high-dose Jinlu Erxiangyue group was higher than that in the normal group and the model group (P <0.05). Conclusion: Jinsuo Erxian Decoction can improve serum T level in kidney deficiency model mice and increase the weight of accessory gland (prostate + seminal vesicle) and body weight in experimental mice.