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目的 :探讨第二原发胰腺癌的临床特征。 方法 :以 96例普通原发胰腺癌作为对照 ,回顾性分析了病理确诊的 32例第二原发胰腺癌的临床特征。 结果 :32例第二原发胰腺癌 1 5例 (4 6 .9% )发生于乳腺癌、胃癌之后。性别、年龄、部位、临床症状、常规实验室检查及肿瘤标志物检测与普通进展期胰腺癌具有可比性 ,仅年龄略为提前 ,消化不良稍多 ,腹痛、黄疸比例稍降。B型超声、CT、MRI、逆行胰胆管造影诊断敏感率较普通胰腺癌高。处于Ⅰ期者仅 2例 (6 .3% )。总体半年存活率为5 0 .0 % ,较普通胰腺癌略低。病理显示 84 .4 %为腺癌 ,分化差。 结论 :第二原发胰腺癌症状更不典型 ,诊断更为滞后 ,预后更差 ,故应加强联系与第一次癌肿的早期检测手段 (如肿瘤标志物 )研究。
Objective: To investigate the clinical features of second primary pancreatic cancer. Methods: 96 cases of primary pancreatic cancer as a control, retrospectively analyzed the pathological diagnosis of 32 cases of second primary pancreatic cancer clinical features. Results: Thirty-two cases of second primary pancreatic cancer (46.9%) occurred after breast cancer and gastric cancer. Sex, age, location, clinical symptoms, routine laboratory tests and tumor markers were comparable with those of normal advanced pancreatic cancer. Only slightly older age, slightly more dyspepsia, and lower rates of abdominal pain and jaundice. B-mode ultrasound, CT, MRI, retrograde cholangiopancreatography diagnostic sensitivity is higher than normal pancreatic cancer. In the first phase were only 2 cases (6.3%). Overall half-year survival rate of 50.0%, slightly lower than normal pancreatic cancer. Pathology showed 84.4% of adenocarcinoma, poorly differentiated. CONCLUSIONS: The second primary pancreatic cancer is more atypical, with more delayed diagnosis and poorer prognosis. Therefore, studies should be strengthened on the early detection of tumor associated with the first cancer (such as tumor markers).