Histone methyltransferase TXRl is required for both H3 and H3.3lysine 27 methylation in the well-kno

• 作 者: Xiaolu Zhao Yuanyuan Wang Yuru
• 机 构: InstituteofEvolution&,MarineBiodiversity,DepartmentofPathology,LaboratoryforMarineBiologyandBiote
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2017年3期
• 关键词: 嗜热四膜虫 原生动物 甲基化 DNA复制 纤毛 相关蛋白 组蛋白 修饰酶 replication histone TXR1 Tetrahytnena subst
• 基金项目: supported by the Natural Science Foundation of China （31470064,31522051 to Shan Gao）, the National Institutes of Health（R01GM087343 to Yifan Liu）, AoShan Talents Program supported by Qingdao National

DNA replication elongation is tightly controlled by histone-modifying enzymes.Our previous studies showed that the histone methytransferase TXRl(Tetrahymena Trithorax related protein 1) specifically catalyzes H3K27 monomethylation and affects DNA replicat