CRISPR/Cas9 system： a powerful technology for in vivo and ex vivo gene therapy

• 作 者: Xiaohui Zhang Liren Wang Mingy
• 机 构: ShanghaiKeyLaboratoryofRegulatoryBiology
• 出 处: 中国科学：生命科学英文版
• 发表日期: 2017年5期
• 关键词: 基因治疗 技术 生物基因组 系统 体外 体内 编辑工具 基础研究 CRISPR/Cas9 gene therapy in vivo ex vivo
• 基金项目: supported by the National Natural Science Foundation of China （31371455, 31171318 to Dali Li, 81330049 to Mingyao Liu）, the Science and Technology Commission of Shanghai Municipality （14140900300 to D

CRISPR/Cas9 is a versatile genome-editing tool which is widely used for modifying the genome of both prokaryotic and eukaryotic organisms for basic research and applications. An increasing number of reports have demonstrated that CRISPR/Cas9-mediated geno