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目的 :探讨肾素 -血管紧张素Ⅱ -醛固酮系统 (RAS)在早期糖尿病肾病患者中变化的意义 ;方法 :观察了 5 2例早期糖尿病肾病患者的肾素、血管紧张素Ⅱ、醛固酮 (PRA、AⅡ、Ald)的变化 ;结果 :早期糖肾病患者其肾素、血管紧张素Ⅱ增高与糖尿病无肾病组比较差别有显著性 (P <0 .0 5 ) ,而与醛固酮水平差别无显著性 (P >0 .0 5 ) ;结论 :测定血清PRA、AⅡ、Ald浓度可指导临床用药、估计预后、判断治疗效果 ,并为ACEI治疗早期糖尿病肾病提供理论依据
Objective: To investigate the significance of renin - angiotensin Ⅱ - aldosterone system (RAS) in patients with early diabetic nephropathy.Methods: Renin, angiotensin Ⅱ, aldosterone (PRA, AⅡ, Ald) .Results: In patients with early stage of diabetic nephropathy, the increase of renin and angiotensin Ⅱ was significantly different from that of non-nephropathy group (P0.05), but no significant difference with aldosterone level P> 0.05) .Conclusion: Determination of serum PRA, AII, Ald concentration can guide the clinical medication, prognosis, to determine the therapeutic effect, and provide a theoretical basis for the treatment of early diabetic nephropathy ACEI