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长非编码RNA(long non-coding RNA,lncRNA)肺癌转移相关转录本1(metastasis-associated lung adenocarcinoma transcript 1,MALAT-1)在肿瘤发生及演进中的作用逐渐受到重视,其与多种肿瘤的发生发展密切相关。MALAT-1定位于人染色体11q13,首先在非小细胞肺癌中被发现并被命名,随后被证实在肝细胞癌、膀胱癌及宫颈癌等肿瘤中也存在异常表达。MALAT-1属于核内保留RNA,主要通过与细胞核内多种蛋白质相互作用,在转录水平和转录后水平参与基因的表达调控。有必要就MALAT-1的发现、结构、作用机制及在肿瘤中的生物学功能等做一综述。
The role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) in tumorigenesis and progression is gradually being emphasized. The occurrence and development are closely related. MALAT-1 is located on human chromosome 11q13, was first found in non-small cell lung cancer and named, then confirmed in hepatocellular carcinoma, bladder cancer and cervical cancer and other tumors are also abnormal expression. MALAT-1, a conserved nuclear RNA, participates in the regulation of gene expression at the transcriptional and post-transcriptional levels, mainly through interactions with multiple proteins in the nucleus. It is necessary to review the discovery, structure, mechanism of action and biological function of MALAT-1 in tumor.