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目的观察重组人脑利钠肽(rh-BNP)联合硝普钠治疗急性失代偿性心力衰竭(ADHF)患者的治疗效果。方法 68例ADHF患者随机分成观察组与对照组,各34例。对照组应用硝普钠治疗,观察组应用rh-BNP联合硝普钠治疗。观察两组疗效。结果观察组左心室射血分数(LVEF)、血浆脑利钠肽(BNP)水平改善均优于对照组(P<0.05);两组左心室舒张末期内径(LVEDD)与不良反应发生率比较差异无统计学意义(P>0.05)。结论应用rh-BNP联合硝普钠治疗ADHF患者,疗效显著。
Objective To observe the therapeutic effect of recombinant human brain natriuretic peptide (rh-BNP) combined with sodium nitroprusside in patients with acute decompensated heart failure (ADHF). Methods Sixty-eight patients with ADHF were randomly divided into observation group and control group, with 34 cases in each group. The control group was treated with sodium nitroprusside and the observation group was treated with rh-BNP combined with sodium nitroprusside. The two groups were observed. Results The left ventricular ejection fraction (LVEF) and plasma brain natriuretic peptide (BNP) levels in observation group were better than those in control group (P <0.05). There was significant difference between the two groups in the incidence of left ventricular end-diastolic diameter (LVEDD) No statistical significance (P> 0.05). Conclusion rh-BNP combined with sodium nitroprusside in the treatment of ADHF patients with significant effect.