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目的探讨术前介入化疗对Ⅰb2～Ⅱa期巨块型宫颈癌的近期疗效。方法将65例Ⅰb2～Ⅱa期巨块型宫颈癌患者随机分为2组:介入组33例术前予以介入化疗(表阿霉素40～80mg,顺铂40～80mg,5-氟脲嘧啶0.75～1.0g,丝裂霉素10～20mg),介入治疗后3周进行宫颈癌根治术;对照组32例直接行常规宫颈癌根治术。结果介入组介入治疗后肿瘤退缩明显,介入前、后肿瘤直径分别为(4.79±0.93)、(2.98±1.18)cm,缩小(1.81±1.21)cm,缩小百分比达(37.38±24.35)%,介入前、后肿瘤大小差异有统计学意义(P<0.05)。术后介入组宫旁浸润、阴道残端浸润及脉管癌栓发生率均较对照组低(P均<0.05)。结论Ⅰb2～Ⅱa巨块型宫颈癌根治术前介入化疗有一定近期疗效。
Objective To investigate the short-term curative effect of preoperative interventional chemotherapy on massive cervical cancer Ⅰb2 ~ Ⅱa. Methods Sixty-five patients with stage Ⅰb2 ~ Ⅱa massive cervical cancer were randomly divided into two groups: interventional group of 33 patients undergoing preoperative chemotherapy (epirubicin 40 ~ 80mg, cisplatin 40 ~ 80mg, 5-fluorouracil 0.75 ~ 1.0g, mitomycin 10 ~ 20mg), 3 weeks after interventional treatment of cervical cancer radical; control group of 32 cases of conventional cervical cancer radical surgery. Results The tumor shrinks significantly after interventional treatment in intervention group. The diameter of tumor before and after intervention was (4.79 ± 0.93) and (2.98 ± 1.18) cm respectively, decreased by 1.81 ± 1.21 cm and decreased by 37.38 ± 24.35% The tumor size before and after the difference was statistically significant (P <0.05). There was a lower incidence of uterine infiltration, invasion of vaginal stumps, and incidence of vascular tumor thrombus in the postoperative intervention group (all P <0.05). Conclusion Ⅰb2 ~ Ⅱ a massive cervical cancer interventional chemotherapy before a certain short-term effect.