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目的观察临床急性冠脉综合征(ACS)病人血清和肽素浓度的变化,并探讨其临床意义。方法入选临床观察对象86例,其中包括不稳定型心绞痛组(UAP组)31例,急性心肌梗死(AMI组)25例,另外以正常健康人30例为正常对照组。所有入选者均测定血压(BP)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高敏C-反应蛋白(hs-CRP)和血清和肽素浓度。结果①与正常对照组比较,UAP组和AMI组的BP、TG、TC、LDL-C、hs-CRP和血清和肽素浓度均显著升高。②与UAP组比较,AMI组BP、TG、TC、LDL-C无明显差异,但是血清hs-CRP、和肽素浓度均明显升高(P﹤0.05)。③ACS患者的血清和肽素浓度与hs-CRP定量有明显的正相关性(r=0.296,P﹤0.05)。结论 ACS患者血清和肽素浓度显著升高,并与病情的严重程度和炎症反应相关,可以作为ACS的重要实验室观察指标。
Objective To observe the changes of serum copeptin concentrations in patients with clinical acute coronary syndrome (ACS) and to explore its clinical significance. Methods A total of 86 patients were enrolled in this study, including 31 patients with unstable angina pectoris (UAP group) and 25 patients with acute myocardial infarction (AMI group), and 30 normal healthy subjects as normal control group. All participants were evaluated for blood pressure (BP), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high sensitivity C-reactive protein (hs-CRP) and serum copeptin concentrations . Results ① Compared with the normal control group, the concentrations of BP, TG, TC, LDL-C, hs-CRP and serum copeptin in UAP group and AMI group were significantly increased. ② Compared with UAP group, there was no significant difference in BP, TG, TC and LDL-C in AMI group, but serum hs-CRP and copeptin concentrations were significantly increased (P <0.05). ③ Serum copeptin concentrations in ACS patients were positively correlated with the hs-CRP levels (r = 0.296, P <0.05). Conclusions Serum copeptin concentrations in patients with ACS are significantly elevated, and are correlated with the severity of the disease and the inflammatory response, and may be used as an important laboratory observation index for ACS.