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目的 探讨缺血性脑卒中患者白细胞与血小板的相互作用及其在中风发病过程中的作用机制和临床意义。方法 分别测定４０ 例急性缺血性中风患者富血小板血浆（ＰＲＰ）加患者白细胞前后和加正常人白细胞前后的血小板聚集率和一氧化氮（ＮＯ）含量，同时作白细胞、血小板计数。结果 患者白细胞、血小板数和健康对照组无显著差异。加白细胞前，患者血小板最大聚集率和ＮＯ 含量明显高于对照组（７１．６３±１４．８２）％ 对（６３．２３±１４．３０）％ （ｔ＝ ２．４９１，Ｐ＜ ０．０５）和（０．３８６±０．０２６）μｍ ｏｌ／Ｌ对（０．２９２±０．０２０）μｍ ｏｌ／Ｌ（ｔ＝ １７，４０７，Ｐ＜ ０．００１），加患者白细胞后，血小板最大聚集率为（５１．７１±１５．０２），明显抑制（ｔ＝ ５．９７１，Ｐ＜ ０．００１），ＮＯ 浓度为（０．４９６±０．０７２）μｍ ｏｌ／Ｌ，明显升高（ｔ＝ ９．０９１，Ｐ＜ ０．００１），且血小板聚集抑制和ＮＯ升高呈负相关。加正常白细胞后的血小板聚集率和ＮＯ 浓度分别为（６７．３９±１６．６２）％ 和（０．３９１±０．０２８）μｍ ｏｌ／Ｌ，均无明显变化（ｔ＝ １．２０５，Ｐ＞ ０．０５ 和ｔ＝ ０．８２６，Ｐ＞ ０．０５）。结论?
Objective To investigate the interaction between leukocytes and platelets in patients with ischemic stroke and its role in the pathogenesis of stroke and its clinical significance. Methods The platelet aggregation rate and the content of nitric oxide (NO) in 40 patients with acute ischemic stroke before and after leukocyte enrichment and before and after leukocyte enrichment were measured respectively. Meanwhile, the white blood cell count and platelet count were calculated. Results There was no significant difference in the number of white blood cells, platelets and healthy controls. Before addition of white blood cells, the maximum platelet aggregation rate and the content of NO in the patients were significantly higher than those in the control group (71.63 ± 14.82)% vs 63.23 ± 14.30% (t = 2.491, P <0.05) ) And (0.386 ± 0.026) μm ol / L vs 0.292 ± 0.020 μmol / L (t = 17,407, P <0.001) The concentration of NO was (51.71 ± 15.02) , significantly inhibited (t = 5.971, P <0.001) and the concentration of NO was (0.496 ± 0.072) μm ol / L, (T = 9.091, P <0.001), and the inhibition of platelet aggregation was negatively correlated with the increase of NO. The platelet aggregation rate and NO concentration after adding normal leukocytes were (67.39 ± 16.62)% and (0.391 ± 0.028) μmol / L respectively, with no significant change (t = 1.205, P > 0.05 and t = 0.826, P> 0.05). in conclusion?