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目的：探讨前列腺素Ｅ２（ＰＧＥ２）在胃癌中的应用价值。方法：用放免法测定３０例胃癌、３０例良性胃病患者和２３例健康人外周血单个核细胞产生ＰＧＥ２水平，同时还检测了ＴＮＦα和ＩＬ－２受体（ＩＬ－２Ｒ）表达水平，并使用消炎痛体外干预。结果：胃癌患者ＰＧＥ２和ＴＮＦα水平显著高于正常对照及良性胃病组（Ｐ＜００５），而胃癌患者ＩＬ－２Ｒ表达水平显著降低（Ｐ＜００１）；消炎痛体外干预可显著提高胃癌患者ＴＮＦα和ＩＬ－２Ｒ表达水平（Ｐ＜００１）。结论：研究ＰＧＥ２产生情况，对反映胃癌患者免疫功能状态及改善免疫治疗效果可能有一定意义
Objective: To investigate the application of prostaglandin E2 (PGE2) in gastric cancer. METHODS: PGE2 levels in peripheral blood mononuclear cells from 30 patients with gastric cancer, 30 patients with benign gastropathy, and 23 healthy controls were determined by radioimmunoassay. The levels of TNFα and IL-2 receptor (IL-2R) were also measured. Indomethacin in vitro intervention. Results: The levels of PGE2 and TNFα in gastric cancer patients were significantly higher than those in normal controls and benign gastropathy group (P<005), while the expression of IL-2R in gastric cancer patients was significantly decreased (P<001). In vitro treatment with indomethacin can significantly improve The expression of TNFα and IL-2R in gastric cancer patients (P<001). Conclusion: The study of PGE2 production may be of significance in reflecting the immune function of gastric cancer patients and improving the efficacy of immunotherapy.