应用神经抑制药物后发生帕金森综合征的风险有多大?

• 作 者: Noyes K. Holloway R.G. 刘凯
• 机 构: Department of Community and Preventive Medicine University of Rochester Box 644 601 Elmwood Avenue
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2006年10期
• 关键词: 帕金森综合征 神经抑制 多大 医疗保险 多变量模型 抗精神病药 药物治疗 自我报告

Use of neuroleptic medications is common among elderly patients. Using multivariate models, the authors found that use of antipsychotic medications, age, and disability were strong predictors of developing self- reported Parkinson disease (PD) in the subsequent year among 1992 to 2000 Medicare Current Beneficiary Survey participants. Although more research is needed, these data suggest that 126 Medicare beneficiaries would need to be treated with neuroleptic medications to cause one additional case of self- reported PD.

Use of neuroleptic medications is common among elderly patients. Using multivariate models, the authors found that use of antipsychotic medications, age, and disability were strong predictors of developing self- reported Parkinson disease (PD) in the subsequent year among 1992 to 2000 Medicare Current Beneficiary Survey participants. Although more research is needed, these data suggest that 126 Medicare beneficiaries would need to be treated with neuroleptic medications to cause one additional case of-prescribed PD.