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肥胖是一种低度炎性反应,通常把胰岛素抵抗的患病机制和代谢综合征联系起来。随着研究的深入,人们认为Toll样受体4(TLR4)可能是肥胖致低度炎性反应的一个关键调节点。以下主要对TLR4与肥胖个体胰岛抵抗的研究现状和发展作一综述。
Obesity is a low-grade inflammatory reaction that usually links the pathogenesis of insulin resistance with metabolic syndrome. With further research, it is thought that Toll-like receptor 4 (TLR4) may be a key regulation point of obesity-induced low-grade inflammatory reaction. The following mainly summarizes the research status and development of islet resistance of TLR4 and obese individuals.