【摘 要】
：
A variety of nano-engineered photosensitizers have been developed for photodynamic therapy (PDT) of cancer diseases. However, traditional nano-engineering methods usually cannot avoid drug leak-age and premature release, and have disadvantages such as low
【机 构】
：
State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024,China;Shandong
论文部分内容阅读
A variety of nano-engineered photosensitizers have been developed for photodynamic therapy (PDT) of cancer diseases. However, traditional nano-engineering methods usually cannot avoid drug leak-age and premature release, and have disadvantages such as low drug load and inaccurate release. The self-assembly strategy based on amphiphilic peptides has been considered to be more attractive nano-engineering method. Here we developed novel acid-activatable self-assembled nanophotosensitiz-ers based on an amphiphilic peptide derivative. The peptide derivative was synthesized from a fluorescein molecule with thermally activated delayed fluorescence (TADF). The self-assembled nanophotosensitizers can specifically enter the tumor cells and disassemble inside lysosomes companied with“turn-on”fluo-rescence and photodynamic therapy effect. Such smart nanophotosensitizers will open new opportunities for cancer theranostics.
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