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目的 观察钙拮抗剂地尔硫 (Dil)对空腹大鼠、葡萄糖负荷大鼠以及肾上腺素诱发高血糖大鼠血浆胰岛素水平的影响。方法 采用放射免疫测定法测定血浆胰岛素含量。结果 空腹大鼠灌胃给予 10mg·kg-1和 10 0mg·kg-1Dil后 ,胰岛素水平升高 ;与对照组相比 ,Dil 10 0mg·kg-1给药后 30min使胰岛素水平增加了 1 31倍。在糖耐量试验中 ,Dil两剂量均升高胰岛素水平。在肾上腺素诱发高血糖大鼠 ,Dil 10 0mg·kg-1仅在给药后 1h轻度升高血浆胰岛素水平。结论 Dil升高空腹大鼠和葡萄糖负荷大鼠血浆胰岛素水平 ,该作用除与药物诱发的血糖升高有关外 ,可能也与Dil的某些尚未发现的作用有关。
Objective To observe the effects of Dil, a calcium antagonist, on plasma insulin in fasting rats, glucose-loaded rats and epinephrine-induced hyperglycemic rats. Methods Plasma insulin was measured by radioimmunoassay. Results Compared with the control group, the fasting insulin levels increased after intragastric administration of 10 mg · kg-1 and 100 mg · kg-1Dil in rats. Compared with the control group, insulin levels increased by 131% after Dil 10 0 mg · kg-1 administration Times In glucose tolerance test, Dil both increased insulin levels. In adrenaline-induced hyperglycemic rats, Dil 10 0 mg · kg-1 slightly elevated plasma insulin levels only 1 h after administration. Conclusion Dil increases plasma insulin level in fasting rats and glucose-loaded rats, which may be related to some undiscovered effects of Dil, besides being related to drug-induced hyperglycemia.