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氟喹诺酮具有抗菌谱广和优良的药代动力学特性而成为重要的抗菌药.然而,大多数氟喹诺酮(如环丙沙星、洛美沙星、诺氟沙星和氧氟沙星)对厌氧菌活性一般,对脆弱类杆菌活性极差.而新喹诺酮对厌氧菌,尤其对脆弱类杆菌活性有明显改善(如WIN57273,Bay y3118和CI960抑菌浓度均≤2μg/ml).DU-6859a是一种新口服喹诺酮,它具有副作用少,药代动力学特性佳等特点.在第33届抗菌剂和化疗会议上发表的许多报告指出DU-6859a比所有类似化合物的抗菌活性都强,而且对许多厌氧菌有活性.
Fluoroquinolones have become an important antibacterial agent with broad antibacterial spectrum and excellent pharmacokinetic properties However, most fluoroquinolones (such as ciprofloxacin, lomefloxacin, norfloxacin and ofloxacin) The activity of Oxygen bacteria was normal and the activity of Bacteroides fragilis was very poor, while the new Quinolone had a significant improvement on the activity of Anaerobic bacteria, especially Bacteroides fragilis (for example, the inhibitory concentrations of WIN57273, Bay y3118 and CI960 were both ≤2μg / ml) 6859a is a new oral quinolone with few side effects and good pharmacokinetic properties.Many reports published at the 33rd Antimicrobial and Chemotherapy Conference point out that DU-6859a has more antibacterial activity than all similar compounds, It is also active against many anaerobic bacteria.