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目的:探讨CT引导下无水酒精碘油乳剂注入联合CT引导下射频消融(RFA)治疗小肝癌的临床疗效。方法:选择确诊为原发性肝癌并无法行手术切除患者36例,先行CT引导下无水酒精与碘油混合液于肿瘤注入,术后1-2周行CT引导下RFA消融治疗。结果:全组病例均获得随访,无手术死亡及严重并发症发生,术后经增强影像学复查肿瘤均消融(100%),AFP明显降低者35例(97.2%),其中30例(83.3%)AFP恢复正常;1个月、3个月、6个月及1年复发率分别为100%(36/36)、94.4%(34/36)、83.3%(30/36)、77.8(28/36)。结论:综合序贯应用CT引导下无水酒精与碘油混合液于肿瘤注入联合RFA是治疗无法手术切除原发性肝癌安全有效的方法,提高了肿瘤局部治疗效果,改善了患者的临床症状,延长了患者生存时间。
Objective: To investigate the clinical effect of CT guided dry injection of lipiodol emulsion combined with radiofrequency catheter ablation (RFA) in the treatment of small hepatocellular carcinoma. Methods: Totally 36 patients who were diagnosed as primary hepatocellular carcinoma without surgical resection were enrolled. Tumor was infused with a mixture of anhydrous alcohol and lipiodol under the guidance of CT, and CT guided RFA ablation was performed 1-2 weeks after operation. Results: All the patients were followed up without any operative death and serious complications. All the tumors were ablated by enhanced imaging (100%) and 35 (97.2%) with AFP were significantly reduced. Among them, 30 (83.3% ) AFP returned to normal; the recurrence rates at 1 month, 3 months, 6 months and 1 year were 100% (36/36), 94.4% (34/36), 83.3% (30/36), 77.8 / 36). Conclusions: The comprehensive and sequential application of CT-guided combination of anhydrous alcohol and lipiodol in tumor injection combined with RFA is a safe and effective method for the treatment of unresectable primary liver cancer, which improves the local treatment effect of the tumor and improves the clinical symptoms, Extend the patient’s survival time.