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为探明镉和铜对交感神经作用的机理,作者研究了染镉大鼠下丘脑和中脑的金属分布以及与该部位儿茶酚胺之间的关系。实验用Wistar雌性大鼠(体重100 g),投与由镉(氯化镉)3、10、30 mg/kg,和铜(硫酸铜)200 mg/kg组合成的8种饲料90天。脑组织用Glowinsk等人的方法分离,金属用原子吸收分光光度计测定。镉10、30 mg/kg加铜200 mg/kg组和铜镉单独饲料组动物,体重增加率出现明显的抑制。大脑皮质的重量在镉和铜同时投与组比单
To investigate the mechanism of sympathetic effects of cadmium and copper, we investigated the metal distribution in the hypothalamus and midbrain of cadmium-exposed rats and their relationship with catecholamines at this site. Experimental Wistar female rats (weighing 100 g) were dosed eight diets consisting of 3, 10, 30 mg / kg of cadmium (cadmium chloride) and 200 mg / kg of copper (copper sulfate) for 90 days. Brain tissue was isolated by the method of Glowinsk et al., And the metal was determined by atomic absorption spectrophotometer. Cadmium 10,30 mg / kg plus copper 200 mg / kg group and copper and cadmium alone group animals, body weight gain significantly inhibited. The weight of the cerebral cortex at the same time cadmium and copper than the group administered alone