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目的 探讨人工流产术前应用小剂量米索前列醇对宫颈的扩张作用。方法 选择孕３５ ～７０ｄ 要求人流的孕妇７５例，随机分为Ａ、Ｂ 两组，Ａ 组于人流术前２ｈ 口服米索前列醇０ ．２ ｍ ｇ ；Ｂ 组不服药。结果 Ａ、Ｂ 两组术时宫颈扩张总有效率分别为８４ ．６２ ％ 、１１ ．１１ ％ ；Ａ、Ｂ 两组人流综合症发生率分别为０ 、２２ ．２２ ％ ；其他副反应的发生率分别为２０ ．５１ ％ 、５５ ．５６ ％ ；Ａ组术中出血量明显低于 Ｂ 组； 差异均有显著性意义（ Ｐ ＜０ ．００５） 。结论 人工流产术前口服小剂量米索前列醇可有效扩张宫颈，减少术中出血，减少人流综合症及副反应发生。
Objective To investigate the effect of low dose misoprostol on cervical dilatation before induced abortion. Methods Seventy-five pregnant women, who were required to have abortions from 35 to 70 days of pregnancy, were randomly divided into A and B groups. A group received oral misoprostol 2 hours before abortion. 2 m g; Group B did not take medicine. Results The total effective rates of cervical dilatation in operation A and B were 84. 62%, 11. 11%; A, B two groups the incidence of flow syndrome were 0, 22. 22%; the incidence of other side effects were 20. 51%, 55. 56% in group A; the blood loss in group A was significantly lower than that in group B; the difference was significant (P <0 .005). Conclusions Oral administration of small doses of misoprostol before operation can effectively expand the cervix, reduce intraoperative bleeding and reduce the incidence of flow syndrome and side effects.