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目的:分析532例高龄孕妇妊娠中期唐氏筛查的结果。方法:收集532例在我院进行妊娠中期唐氏筛查的高龄孕妇,其中观察组孕妇481例,对照组孕妇51例,对照比较两组孕妇唐氏筛查阳性率、唐氏初筛检出率、羊水穿刺结果和随访妊娠结局。结果:对照组孕妇唐氏初筛阳性率(9.0%)低于观察组(20.1%);对照组唐氏儿发生率(2.3%)低于观察组(9.9%);对照组染色体核型异常发生率也低于观察组;对照组唐氏初筛软件对唐氏儿的检出率低于观察组(P<0.05);对照组不良妊娠结局发生率(3.5%)低于观察组(P<0.05)。结论:高龄孕妇孕中期唐氏筛查,不仅能对高龄孕妇得唐氏综合征有很好的预防作用,而且还能降低高龄孕妇发生不良结局的风险。
Objective: To analyze the results of Down’s screening in the middle of pregnancy in 532 elderly pregnant women. Methods: A total of 532 elderly pregnant women were enrolled in our study. The pregnant women in the observation group were 481 pregnant women and 51 pregnant women in the control group. The Down’s screening positive rate was compared between the two groups, Rate, amniocentesis results and follow-up pregnancy outcome. Results: The positive rate of Down’s screening in pregnant women in control group (9.0%) was lower than that in observation group (20.1%). The incidence of Down’s syndrome in control group (2.3%) was lower than that of observation group (9.9% (P <0.05). The incidence of adverse pregnancy outcomes in the control group (3.5%) was lower than that in the observation group (P <0.05) <0.05). Conclusion: Down’s screening of pregnant women during the second trimester can not only prevent down syndrome in elderly pregnant women, but also reduce the risk of adverse outcomes in the elderly pregnant women.